Canabidiol: o medicamento derivado da maconha

A Cannabis sativa é uma planta que possui mais de 500 compostos, dos quais pelo menos 100 são canabinoides. O Canabidiol é um deles! Vamos ver quais seus efeitos e o seu potencial terapêutico.

Referências

Shohami et al. Endocannabinoids and traumatic brain injury. British Journal of Pharmacology, 2011; 163(7):1402-10. https://doi.org/10.1111/j.1476-5381.2011.01343.x

Volkow ND. The biology and potential therapeutic effects of cannabidiol. Senate Caucus on International Narcotics Control, 2015. http://bit.ly/2qpCLFE

Jones et al. Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure. 2012 Jun;21(5):344-52. https://doi.org/10.1016/j.seizure.2012.03.001

Devinsky et al. Trial of cannabidiol for drug-resistant seizures in the Dravet Syndrome. N Engl J Med. 2017; 376(21):2011-20. https://doi.org/10.1056/NEJMoa1611618

Martín-Moreno et al. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease. Mol Pharmacol. 2011; 79(6):964-973. https://doi.org/10.1124/mol.111.071290

García-Arencibia et al. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain Res. 2007; 1134(1):162-70. https://doi.org/10.1016/j.brainres.2006.11.063

Pazos et al. Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs:role of 5HT(1A) and CB2 receptors. Neuropharmacology. 2013; 71:282-91. https://doi.org/10.1016/j.neuropharm.2013.03.027

McAllister et al. The antitumor activity of plant-derived non-psychoactive cannabinoids. J Neuroimmune Pharmacol. 2015; 10(2):255-67. https://doi.org/10.1007/s11481-015-9608-y

Guimaraes et al. Antianxiety effect of cannabidiol in the elevated plus-maze. Psychopharmacology (Berl). 1990; 100(4):558–9. https://doi.org/10.1007/BF02244012

Schier et al. Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug. Rev Bras Psiquiatr. 2012; 34(Supl1):S104-S117. https://doi.org/10.1590/S1516-44462012000500008

Das et al. Cannabidiol enhances consolidation of explicit fear extinction in humans. Psychopharmacology (Berl). 2013; 226(4):781-92. https://doi.org/10.1007/s00213-012-2955-y

Bergamaschi et al. Safety and side effects of cannabidiol, a Cannabis sativa constituent. Curr Drug Saf. 2011; 6(4):237-49. https://doi.org/10.2174/157488611798280924

Maconha passa a fazer parte da lista de plantas medicinais da Anvisa. Folha de São Paulo, 2017. http://bit.ly/2rXfCYw

Cancian N. Anvisa libera uso medicinal de derivado da maconha. Folha de São Paulo, 2015. http://bit.ly/2rXkrBb

Anvisa define regras para venda de medicamento à base de canabidiol. Portal Brasil, 2016. http://bit.ly/2rWV56D