Antibióticos: o que são? de onde vêm? como agem?

Vamos ver o que são os antibióticos, como eles atuam e o que é a tal da resistência.

Referências: Wright GD. Q&A: Antibiotic resistance: where does it come from and what can we do about it? BMC Biology, 2010; 8:123. https://doi.org/10.1186/1741-7007-8-123 World Health Organization. Antibiotic Resistance - Fact sheet. 2016. http://bit.ly/2sNZBnG Service R. Superantibiotic is 25,000 times more potent than its predecessor. Science, 2017. https://doi.org/10.1126/science.aan6906 Okano A, Isley NA, Boger DL. Peripheral modifications of [Ψ[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics, PNAS Early Edition, 2017. https://doi.org/10.1073/pnas.1704125114 Vester B, Long KS. Antibiotic Resistance in Bacteria Caused by Modified Nucleosides in 23S Ribosomal RNA. in: Grosjean H (ed.). DNA and RNA Modification Enzymes: Structure, Mechanism, Function and Evolution. Landes Bioscience, 2009. http://bit.ly/2sNYSmk Aldred KJ, Kerns RJ, Osheroff N. Mechanism of Quinolone Action and Resistance. Biochemistry, 2014; 53(10):1565-74. https://doi.org/10.1021/bi5000564 Poole K. Efflux pumps as antimicrobial resistance mechanisms. Ann Med, 2007; 39(3):162-76. https://doi.org/10.1080/0785389070119... Neves HI. Unindo forças com o inimigo. Café na bancada, 2016. http://bit.ly/2sNVcAV